- Verona Pharma has confirmed highly positive headline data from a Phase IIa study that assessed the bronchodilator effect of nebulised RPL554 administered on top of salbutamol and ipratropium bromide in patients with chronic obstructive pulmonary disorder (COPD).

RPL554 is a novel inhaled dual PDE3/PDE4 inhibitor with both bronchodilator and anti-inflammatory properties in the same molecule, which is currently in development as a nebulised treatment for acute exacerbations in COPD patients in a hospital or for maintenance treatment in a home-care setting.

Such patients typically require additional bronchodilation, despite being on approved COPD bronchodilator medications such as salbutamol, a beta2-agonist, and ipratropium bromide, an anti-muscarinic.

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