- UK stocks opened lower on Friday after a disappointing earnings update from Royal Bank of Scotland laid bare the negative impact that Brexit uncertainty is having on the UK economy.

At 0901, the FTSE 100 was down 29.70 points, or 0.3%, at 7.414.43.

RBS slumped 4.5% after it booked a fall in first-quarter profits and warned on its annual guidance, a day after announcing chief executive Ross McEwan was leaving.

Food delivery company Just Eat fell 3.2%, as investors looked past a 28% jump in first-quarter revenue and focused on slowing order growth in the company's key UK market.

Global advertising giant WPP edged up 0.4% on the back of a modest rise in first-quarter revenue driven by foreign exchange gains. Sales, however, fell 2.8% at an underlying level due to client losses in the US.

Former WPP boss Martin Sorrell's new advertising company S4 Capital gained 2.4% after it acquired Amsterdam-based Caramel Pictures and Sao Paulo-based ProgMedia, for undisclosed sums.

British insurance provider Hastings slumped 8.9% after its first-quarter revenue slipped amid higher claims costs.

Computer services provider Computacenter was having a better morning. Its shares soared 12% after a strong performance in France during the first quarter helped inspire confidence in its full-year guidance.

Educational publisher Pearson, meanwhile, fell 1.0% even as it announced that its underlying sales had grown by 2% in the first quarter, while reiterating its annual earnings guidance.

Pharmaceuticals company AstraZeneca ticked up 0.2% as it more than doubled pre-tax profits in the first quarter and stuck to its full-year guidance.

Flow control and instrumentation company Rotork fell 0.6% after announcing that it expected to achieve 'modest' sales growth in 2019, weighted to the second half.

Drug developer ReNeuron rallied 18% after it recorded positive results from a clinical trial of a treatment for the blindness-causing disease retinitis pigmentosa. Story provided by