- Dr Louise Makin, Chief Executive Officer, exercised 1,285,168 shares in the company on the 16th August 2019 at a price of 0.00p. The Director now holds 2,251,925 shares.

NOTE: Exercise re Nil cost options for:Performance Share Plan 2016-18. Exec Share Option Plan 2010-12. Deferred Share Bonus Plan 2017-19

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